| In this
issue:
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Dr. Neustadt was voted
Best Doctor |
Doctor's Corner
It's been a few months since I last sent out a MIM Health
enewsletter. I hope you have all had a fun, relaxing and healthy
summer. This summer was a bit short here in southwest Montana. It snowed
well into June, but when the summer did finally arrive it was beautiful.
I was honored to have
recently been voted Best
Doctor among all physicians in the area in The Tributary's annual
Best of Bozeman survey. This is the first time a naturopathic doctor has
ever won this category. Winners are determined exclusively by voters, who
respond to the ballots the paper includes in its July issue and online. The
editors wrote about Dr. Neustadt, "It is noteworthy that Dr. Neustadt did
not win 'best naturopathic doctor;' he won best doctor. Perhaps for his
expertise in nutritional biochemistry – his book, A Revolution in Health
through Nutritional Biochemistry, written with Steve Pieczenik, MD,
Ph.D., was released this spring. Perhaps, it is his intuitive and holistic
approach to health care. Perhaps it is for the extra hours he puts in at no
charge. But likely it's the combination of all of these characteristics that
set him apart. This is a big day for naturopaths everywhere.
Congratulations, Dr. Neustadt." Thank you to everyone who voted for me, and
to all my patients who have trusted me to help them.
Additionally in July, an article written by
Dr. Pieczenik and I entitled, Medication-Induced Mitochondrial Damage and
Disease, was published in the journal Molecular Nutrition and Food
Research. Because of our groundbreaking
research into the role mitochondria play in disease, we were approached by a
senior FDA researcher and asked to submit an article on the topic for a
special issue of the journal. Mitochondria are the energy-producing portion
of our cells. Damage to mitochondria is now implicated in nearly every
disease, including diabetes, anxiety disorders, bipolar disorder, cancer,
Alzheimer disease, chronic fatigue syndrome, pain and cardiovascular
disease. We have pioneered the clinical application of testing and
nutritional treatments for mitochondrial damage and its symptoms, and this
invited article is a testament to the groundbreaking work being done at MIM.
Over the years I have been asked about dietary
supplements and, more often than not, patients will show me their dietary
supplements and ask my opinion of them. Unfortunately, most of the time
people are purchasing very poor quality products that really aren't helping
them. They would be better off saving their money and just eating healthier.
Most people should eat healthier, and a good diet is the foundation for
long-term health. However, purchasing dietary supplements can promote your
health and be a very good investment. But most people don't
even understand the basics of how to select a high-quality formula that will
actually help them. This issue's Health Topic is a
Frequently Asked Questions (FAQ) that can help you buy the best quality
dietary supplement.
The Natural Tip this month is about
Butterbur (Petasites hybridus), which has been shown on multiple
clinical trials to be very helpful for decreasing the symptoms of migraines
and allergies. While decreasing symptoms can be very helpful, I still
advocate and strive to help people identify and treat the underlying causes
of disease. This can be done very effectively in many cases with biochemical
testing. More information can be found on the MIM
website by clicking here.
I enjoy sharing new websites and information when I come
across them. I recently learned of a great website that has recipes for kids
with and without special dietary needs. This is discussed in the
Recipe section of the newsletter.
And if you're in Southwest Montana this Saturday,
September 20, come by the Holiday Inn and hear Dr. Neustadt speak on
Naturopathic Pain Management for Cancer Patients at the
Collaborative Cancer Care Symposium.
Wishing you good health,
Dr. Neustadt
And if you're ever interested in reading
back issues of the newsletter, they're posted on the clinic website, at
www.montanaim.com/newsletter.
* * *
Upcoming Appearance: Collaborative Cancer Care
Symposium Dr. Neustadt will be
speaking on September 20 from 2:15- 3:30 PM at the Collaborative
Cancer Care Symposium on Naturopathic Pain Management for cancer
patients. This engaging Collaborative Care symposium will offer
panel discussions and nine hands-on workshops facilitated by
professionals and cancer survivors across Montana currently
practicing a successful Integrative Medicine approach to wellness
and healing. This symposium is FREE with priority given to Montana
families or individuals within one year of cancer treatment.
Registration is required, and space is limited. This year's
symposium will be held at the Holiday Inn in Bozeman. Call the
Cancer Family Network at 406-587-8080 to register.
Health Topic: NBI Guide to Dietary
Supplements As you might
know, I have formulated a line of dietary supplements with my
colleague, Steve Pieczenik, MD, PhD, under our label,
Nutritional Biochemistry, Inc.
(NBI). We've been working extremely hard the last two years to
launch a line of formulas that adhere to the highest manufacturing
practices and contain only the doses and forms of nutrients in them
that have been shown in clinical trials to be effective. For
example, our
Osteo-K formula is the only product on the market with
the form and dose (45 mg) of vitamin K2 (as MK-4) shown in clinical
trials, and confirmed by the Archives of Internal Medicine to
decrease fracture risk by up to 81%, which is better than Fosamax,
without any of the Fosamax side effects.
I cannot understate the importance of
selecting only dietary supplements that have the form and dose of
nutrients shown in clinical trials to work. Many formulas might
have the form of a nutrient, but a dose that is below the
threshold for even helping you. This is called sub-therapeutic
dosing, and in medicine it can literally kill someone.
I am happy to report that our line of NBI
formulas have been picked up by a national distributor,
Natural Partners, Inc.
(NPI), which distributes pharmaceutical-grade dietary supplements to
doctors across the country for use with their patients.
A few months ago we were
speaking with some retailers in Great Falls, MT, when it occurred to
us that we were hearing the same questions over and over. These were
the same questions many of my patients have as well. Namely, people
really are not clear how to evaluate a dietary supplement formula to
determine if it is high quality and if they are getting their
money's worth.
Unfortunately, it's buyer beware out there at
health food stores, and it can be confusing to people when they try
to select a dietary supplement. Most people just purchase the lowest
cost formula, but in most instances they would be better off just
keeping their money, since the benefit from cheap formulas is
negligible.
To help people understand how to shop and get
the best value for their money, we created a Frequently Asked
Questions (FAQ) document, which I am sending to you now in this
newsletter. I hope it helps.
What Are Dietary Supplements?
Dietary supplements are vitamins, minerals,
herbs and other substances meant to improve your health. They can
come as pills, capsules, powders and liquids. It’s important to
realize that they are not intended to replace an optimal diet, but
rather to “supplement” the diet. Dietary
supplements are regulated by the US Food and Drug Administration
(FDA) under the Dietary Supplement Health and Education Act of 1994
(DSHEA). Signed by President Clinton on October 25, 1994, the DSHEA
acknowledges that millions of consumers believe dietary supplements
may help to augment daily diets and provide health benefits.
The provisions of DSHEA define dietary supplements as being:
- a product (other than tobacco) that is intended to
supplement the diet that bears or contains one or more of the
following dietary ingredients: a vitamin, a mineral, an herb or
other botanical, an amino acid, a dietary substance for use by
man to supplement the diet by increasing the total daily intake,
or a concentrate, metabolite, constituent, extract, or
combinations of these ingredients.
- intended for ingestion in pill, capsule, tablet, or liquid
form.
- not represented for use as a conventional food or as the
sole item of a meal or diet.
- labeled as a "dietary supplement."
- products such as an approved new drug, certified antibiotic,
or licensed biologic that was marketed as a dietary supplement
or food before approval, certification, or license (unless the
Secretary of Health and Human Services waives this provision).
Should I take dietary supplements?
Most people would probably benefit from a high quality
dietary supplement. This is because most people do not eat an
optimal diet. A good dietary supplement is a smart insurance
policy. Basically, what a good regimen of dietary supplements,
diet and exercise do is to boost your immune system and prevent
acute and chronic diseases, including heart disease, diabetes,
high blood pressure, dementia and Parkinson’s disease. In
medicine nutrients are even used to treat many diseases;
however, patients must seek out a skilled doctor knowledgeable in
nutritional medicine, since conventional physicians are not
trained in nutrition.
In theory, we should be able
to receive all the nutrition we need from diet alone. But the
fact is that most of us do not.
- Few of us eat the
recommended 5 – 8 servings of fresh fruits and vegetables a
day.
- Our food is often picked before
it is ripe and transported long distances.
- The
soil in which our food is grown has become depleted of
nutrients.
- We rely on quick,
processed foods with our busy lifestyle.
- We live in a highly
toxic world.
- We have individual
health needs and challenges.
A multiple
vitamin and mineral (MVM) supplement does not replace a good
diet. There are compounds in food that just can’t be replaced in
a pill. Evidence shows that a good diet is still your best tool
for staying healthy. However, a good MVM supplement is important
insurance for optimal health.
How do I know if a dietary
supplement is good?
There are three things to look for in
evaluating a dietary supplement. First, it should be
manufactured at an FDA-approved facility that is also GMP-certified.
Manufacturers cannot advertise this on their product labels, so
you’ll need to check their sales literature for this. This
process requires manufacturers test raw materials for
contaminants and quarantine the materials throughout the
manufacturing process.
|
Quality Checklist |
- Capsules (not tablets)
- More than “one-a-day” multivitamin
- Purity and Potency Guaranteed
- FDA-Approved, GMP-certified Manufacturer
- Highly bioavailable forms (no “-oxide” minerals)
- Hypoallergenic
- Avoid “other ingredients” (e.g., binders and
fillers)
|
Second, the best dietary supplements will
also be tested for purity and potency. This costs
companies extra money so they want to advertise this on their
dietary supplements. Look for “tested for purity and potency” or
“purity and potency guaranteed” on the labels. If they are
tested for purity and potency, then the company should have on
file a certificate of analysis for each product. A
certificate of analysis verifies their purity and potency of a
product. You have the right to request copies of certificates of
analysis from dietary supplement companies. If they refuse to
provide this to you then the product may have contaminants such
as toxic metals, bacteria and fungal spores in it. Additionally,
you cannot be guaranteed that what’s on the label is actually
what’s in each capsule or tablet. In fact many studies have
shown that many dietary supplements contain toxic metals and do
not have the amount of nutrients in the capsules/ or tablets
that are listed on the bottle.
Third, when discussing dietary supplements
Dr. Neustadt is fond of saying, “the devil’s in the details.” In
addition to the two requirements mentioned above, when
evaluating a multivitamin and mineral supplement you should look
for three things on the label. One is to check if it’s a tablet versus a capsule. Tablets are generally more
difficult to break apart in your stomach and may pass through
your body without actually being dissolved and without you
absorbing the nutrients. Additionally, companies tend to put
poorly absorbable forms of nutrients in their formula. (More on
this in a few sentences.) Next, is it a one-a-day
multivitamin? If it is, then you’re pretty much guaranteed
that it’s a tablet and that the nutrients it contains are of
exceedingly poor quality. How can you verify this?
The last thing to do is look on the
Supplement Facts label. This is where each ingredient is listed
out in detail. Look for just three things: magnesium, zinc and
copper. If any minerals are in an “oxide” form, then the
product is garbage. This is because these minerals are very
poorly absorbed in their “oxide” form. For example you can only
absorb about 2% of the magnesium as magnesium oxide. This means
that 98% of what you put in your mouth is just passing right
through you and being eliminated in your stool. In fact,
magnesium oxide is so poorly absorbed that it’s used in higher
amounts as a laxative! Companies use the oxide form of minerals
because their very inexpensive. But you’d be better off
eating a few spinach leaves than wasting your money on a dietary
supplement that contains minerals in their oxide forms.
What are
bioavailable forms of nutrients?
Bioavailable Forms
There are better forms of individual
nutrients than others. You get what you pay for. Many lower cost
products will use cheaper forms of vitamins and minerals.
Unfortunately, many times cheaper forms also mean nutrients
which are poorly absorbed or not usable by the body. Below are a
few examples of nutrient choices.
- Vitamin E
The best form of Vitamin E is d-alpha tocopherol with mixed
tocopherols (d-alpha, gamma, beta, and delta). The synthetic
form of Vitamin E is dl-alpha tocopherol. Note that the
difference in labeling is “d” vs. “dl” before the alpha.
“dl” is not a healthy choice.
- Vitamin B12
The best form of Vitamin B12 is methylcobalamin.
Cyanocobalamin is the form in most vitamins and is usually
fine for most people. If someone has chronic disease
however, a methylcobalamin form is recommended.
- Vitamin B6
The active form of B6 is pyridoxine 5-phosphate. This is
usually designated at P-5-P.
- Minerals
There are many forms of minerals which are bonded to
compounds; the physical form of a mineral is usually
designated by the last word of the name. Example: magnesium
citrate or magnesium oxide. Each form has
different amounts of the basic elemental mineral as compared
to the size of the whole compound and will determine how
absorbable the mineral is.
For example: calcium carbonate (this
includes coral calcium) is a large molecule with a lot of
elemental calcium. The large size of this molecule means that it
is not easily absorbed. Calcium carbonate also tends to be
constipating for some people. Calcium citrate, by contrast, is a
smaller form of elemental calcium, and is much more easily
absorbed than the carbonate form. (An interesting note is that
certain antacid medications contain calcium carbonate and are
marketed as a source of calcium. However, because the purpose of
an antacid is to inhibit stomach acid, and stomach acid is
necessary for making minerals available for absorption, the body
has a harder time actually utilizing the calcium!)
Similarly, magnesium oxide is poorly
absorbed and causes water to stay in the intestines, thus
causing a looser stool. Thus, magnesium oxide can be useful to
treat occasional constipation. Alternatively, magnesium citrate
is a better choice because it is more easily absorbed. (Caution,
however, the citrate form may also cause loose stools for some
people.)
There are other forms of mineral compound
chelates including gluconate, aspartate, asparotate, and
lactate. The gluconate form is not recommended.
What does
hypoallergenic mean?
A good dietary supplement will be hypoallergenic, meaning it does not contain wheat, dairy,
soy, or artificial dyes or colorings.
What are “other
ingredients”?
Before you read what the active
ingredients are, read the label for “other ingredients.” Many
supplements contain extra ingredients that may cause side
effects or impair absorption. If you have lots of unnecessary
“other ingredients”, it does not matter how much active
ingredients you have, the MVM supplement is already a poor
choice. We recommend researching any ingredient that is
unfamiliar to you.
The following is not a
comprehensive list. Some “other ingredients” to avoid:
- Glucose,
fructose, dextrose, maltodextrose, corn syrup, sucrose,
lactose. These are sugars and unless these are added for
flavor in children’s chewable vitamins, they are not needed.
As soon as possible, wean your child from a chewable to a
capsule to minimize their dependence on sugar and risk to
their teeth.
- Sorbitol. This is a sugar alcohol, and although is not purely sugar,
it is not beneficial in a vitamin. For diabetics this is an
absolute must for avoidance! Sorbitol can also cause
diarrhea.
- NutraSweet,
Equal, Aspartame, Sucralose, Splenda. These are
artificial sweeteners and are NOT beneficial to the body.
- Polyethylene
glycol. Although non-toxic, this chemical, when used in
large dosages, is a treatment for constipation. It is
unnecessary for use in highly absorbable vitamins.
- Mineral Oil. Mineral oil is derived from petroleum and prevents
absorption of nutrients. Given these two facts, taking a
vitamin with mineral oil does not seem a good choice.
- Canuba Wax. Canuba wax may inhibit the digestion of the ingredients and
make it less absorbable. This is especially true if
digestive weaknesses are already present.
- Dextrin. This is a binding product, making the nutrients less
available for digestion.
- Di-calcium
phosphate. Di-calcium phosphate is an excipient (an
inactive ingredient) and is not available to the body as
calcium. A vitamin labeling both calcium and phosphorus may
be counting the di-calicum phosphate as calcium, but it
really doesn’t add much to the calcium content
nutritionally.
- Any coloring
- Any pharmaceutical glaze
What does GMP
mean?
GMP refers to the Good Manufacturing
Practice Regulations promulgated by the US Food and Drug
Administration (FDA) under the authority of the Federal Food,
Drug, and Cosmetic Act. These regulations require manufacturers
take steps to ensure that their products are safe, pure, and
effective. GMP regulations require a quality approach to
manufacturing, enabling companies to minimize or eliminate
instances of contamination, mixups and errors. This in turn,
protects the consumer from purchasing a product which is not
effective or even dangerous.
Failure of firms to comply with GMP
regulations can result in very serious consequences including
recall, seizure, fines, and jail time. GMP regulations address
issues including recordkeeping, personnel qualifications,
sanitation, cleanliness, equipment verification, process
validation, and complaint handling.
Are there any
potentially toxic nutrients?
While most nutrients in dietary
supplements do not appear to have any toxic side effects, there
are some notable exceptions. For example, very high doses of
vitamin B6 (pyridoxine), a water soluble vitamin, can cause
numbness and tingling in your fingers and arms. This side effect
is generally reversible when you discontinue the vitamin B6.
Similarly, high doses of vitamin B3 (niacin) can cause flushing
(“hot flashes”) and liver damage.
The amount of nutrients in dietary
supplements are by and large too low to cause any problems, but
sometimes people take very high amounts of nutrients because
they read or heard somewhere that they may be helpful. We
caution people against doing this without first discussing it
with a healthcare provider who is an expert in nutritional
medicine. Below is a table of nutrients and their potential
toxicities.
|
Nutrient |
Toxic Dosage |
Symptoms and Diseases |
|
Biotin |
n/a |
No side
effects from oral administration at therapeutic doses have
been reported |
|
Boron |
>10 mg |
No side
effects reported |
|
Calcium |
>2,000 mg |
Drowsiness,
extreme lethargy, impaired absorption of iron, zinc and
manganese, calcium deposits in tissues throughout body,
mimicking cancer on X-ray |
|
Carotene |
>300 mg |
Orange
discoloration of skin, weakness, low blood pressure, weight
loss, low white cell count |
|
Chromium |
>50 mg |
Dermatitis,
intestinal ulcers, kidney and liver impairment |
|
Copper |
15 mg |
Fatigue,
poor memory, depression, insomnia, increased production of
free radicals, may suppress immune function. Violent
vomiting and diarrhea. Cooking acid foods in unlined copper
pots can lead to toxic accumulation of copper. |
|
Fluoride,
acute |
500 mg |
Poisons
several enzymes, (5,000 mg lethal) |
|
Fluoride,
chronic |
5 mg |
Fluorosis
(white patches on teeth), bone abnormalities |
|
Folic acid |
15 mg |
Abdominal
distention, loss of appetite, nausea, sleep disturbances,
may interfere with zinc absorption, may prevent recognition
of vitamin B12 deficiency |
|
Iodine |
2 mg |
Thyroid
impairment, iodine poisoning or sensitivity reaction |
|
Iron |
Variable |
Intestinal
upset, interferes with zinc and copper absorption, loss of
appetite, not safe for those with iron storage disorders
such as hemosiderosis, idiopathic hemochromatosis, or
thalassemias. Toxic build-up in liver, pancreas, and heart |
|
Magnesium |
N/A |
Diarrhea at
large dosages of poorly absorbed forms (like Epsom salts).
Disturbed nervous system function because the
calcium-to-magnesium ratio is unbalanced; catharsis, hazard
to persons with poor kidney function. |
|
Manganese |
75 mg |
Toxicity
only reported in those working in manganese mines or
drinking from contaminated water supplies, which results in
loss of appetite, neurological damage, loss of memory,
hallucinations, hyperirritability, elevation of blood
pressure, liver damage. Mask-like facial expression, blurred
speech, involuntary laughing, spastic gait, hand tremors. |
|
Niacin
(B3), acute |
100 mg |
Transient
flushing, headache, cramps, nausea, vomiting |
|
Niacin
(B3), chronic |
3 gm |
Anorexia,
abnormal glucose tolerance, gastric ulceration, elevated
liver enzymes. Excessive uric acid in blood, possibly
leading to gout. See Thiamin. |
|
Pantothenic
acid (B5) |
High dose |
Occasional
diarrhea. Increased need for thiamin, possibly causing
thiamin deficiency symptoms. |
|
Phosphorous |
High dose |
Distortion
of calcium-to-phosphorus ratio, creating relative deficiency
of calcium. |
|
Potassium |
High dose |
Mental
impairment, weakness. Excessive potassium in blood, causing
muscular paralysis and abnormal heart rhythms. |
|
Pyridoxine
(B6) |
300 mg |
Sensory and
motor impairment. Dependency on high doses, leading to
deficiency symptoms when one returns to normal amounts. |
|
Riboflavin
(B2) |
N/A |
No toxic
effects have been noted. See Thiamin. |
|
Selenium |
750 mcg |
Diabetes,
garlic-breath odor, immune impairment, loss of hair and
nails, irritability, pallor, skin lesions, tooth decay,
nausea, weakness, yellowish skin |
|
Thiamin
(B1) |
N/A |
No toxic
effects noted for humans after oral administration. However,
since B Vitamins are interdependent, excess of one may
produce deficiency of others. |
|
Vitamin A,
acute (infant)* |
75,000 IU |
Anorexia,
bulging fontanelles, hyperirritability, vomiting |
|
Vitamin A,
acute (adult)* |
2 million
IU |
Headache,
drowsiness, nausea, vomiting |
|
Vitamin A,
chronic (infant)* |
10,000 IU |
Premature
epiphyseal bone closing, long bone growth retardation |
|
Vitamin A,
chronic (adult)* |
50,000 IU |
Anorexia,
headache, bluffed vision, loss of hair, bleeding lips,
cracking and peeling skin, muscular stiffness and pain,
severe liver enlargement and damage, anemia, fetal
abnormalities (pregnant women must be very careful),
menstrual irregularities, extreme fatigue, liver damage,
injury to brain and nervous system. |
|
Vitamin B12
(Cobalamin) |
N/A |
No side
effects from oral administration have been reported. (See
thiamin) |
|
Vitamin C,
acute |
10 gm |
Nausea,
diarrhea, flatulence |
|
Vitamin C,
chronic |
3 gm |
Increased
urinary oxalate and uric acid levels in rare cases, impaired
carotene utilization, chelation (binding of vitamin C with
minerals) and resultant loss of minerals may occur, sudden
discontinuation can cause rebound scurvy. Kidney and bladder
stones, urinary tract irritation, increased tendency for
blood to clot, breakdown of red blood cells in persons with
certain common genetic disorders (such as
glucose-6-phosphate dehydrogenase deficiency, common in
persons of African origin), may induce B12 deficiency. |
|
Vitamin D,
acute |
70,000 IU |
Loss of
appetite, nausea, vomiting, diarrhea, headache, excessive
urination, excessive thirst |
|
Vitamin D,
chronic |
10,000 IU |
Weight
loss, pallor, constipation, fever, hypocalcaemia. In
infants, calcium deposits in kidneys and excessive calcium
in blood; in adults, calcium deposits throughout the body
(may be mistaken for cancer) (pregnant women must be
careful), deafness, nausea, kidney stones, fragile bones,
high blood pressure, high blood cholesterol, increased lead
absorption. |
|
Vitamin E |
1,000 IU |
The safe
dose is probably over 2,000, but some people experience
weakness, fatigue, exacerbation of hypertension, increased
activity of anticoagulants at 1,000 IU. |
|
Vitamin K |
|
No known
toxicity with natural vitamin K (vitamin K1 and K2).
Synthetic vitamin K (vitamin K3) can be toxic. |
|
Zinc |
75 mg |
Gastrointestinal irritation, vomiting, adverse changes in
HDL/LDL cholesterol ratios, impaired immunity. Nausea,
anemia, bleeding in stomach, premature birth and stillbirth,
abdominal pain, fever. Can aggravate marginal copper
deficiency. May produce atherosclerosis. |
*Note: Most multivitamin formulas do not
contain vitamin A. Rather they contain beta-carotene, which the body
converts to vitamin A. Dietary supplement labels will say, Vitamin A
(as Beta Carotene). There is no toxicity associated with taking
beta-carotene, since the body will only convert as much
beta-carotene to vitamin A that it needs.
Should any Nutrients
Be Balanced with other Nutrients?
Yes. Frequently dietary supplement
manufacturers will combine nutrients in ways that are potentially
harmful. In other cases they don’t even include nutrients that
should be there to protect someone from toxicity. For example, zinc
and copper must be balanced in about a 10-to-1 ratio or serious
disease can result. That is, for every 10 mg of zinc you need about
1 mg of copper. This is because high amounts of zinc that are not
balanced with copper can cause a copper deficiency. This can result
in anemia, fatigue and breathing difficulties. This is exactly what
happened to Dr. Pieczenik. He was taking zinc because he read that
it could boost his immune system. But the store-bought dietary
supplements with high zinc did not contain any copper. This lead to
a copper deficiency, which was identified by laboratory analysis, an
inability to produce epinephrine, which allows the lung to dilate
for breathing, and adult onset asthma. Once his copper deficiency
was corrected he no longer had asthma.
Are there
Contaminants in Dietary Supplements?
Unfortunately, yes. Many studies have been
published recently documenting toxic contaminants in dietary
supplements. Toxic metals identified in dietary supplements include
lead, arsenic and mercury at extremely high doses. All of these
toxic metals were contained in dietary supplements with raw
materials from China. contaminants found in dietary supplements
include pesticides, dangerous fungal spores, bacteria, hormone and
even some drugs. To ensure the safety of all its products, NBI pays
extra to have every batch of its dietary supplements
independently tested for authenticity, potency, heavy metals,
solvent residue, herbicide and pesticide residue, aflatoxins,
stability and bacteria, yeast and mold counts. If your dietary
supplement manufacturer does not do this, you may very well be
putting your health at risk. |
|
*
* *
|
Natural Tip: Butterbur for Migraines
and Allergies
Butterbur (Petasites hybridus) is a member of the
Asteraceae (Compositae) family, which also includes sunflower (Helianthus
spp.), echinaceae (Echinaceae spp.), artichoke (Cynara scolymus) and milk
thistle (Silybum marianum). Butterbur is native to Europe, northern Africa
and southwestern Asia and grows up to three feet tall. The plant prefers
wet, marshy ground, and is found growing in damp forests and adjacent rivers
or streams. In the Middle Ages butterbur was used to treat plague and fever,
while during the 17th century it was prescribed for coughs, asthma and skin
wounds. The genus, Petasites, comes form the Greek, “petasos,” which is a
felt hat worn by shepherds. This is because the large leaves, which can
measure up to three feet in diameter, have a soft downy texture. The common
name, “butterbur,” came from one of its historical uses, which was to wrap
butter with the leaves during warm weather. In
modern times, the primary therapeutic uses of butterbur are to prevent
migraine headaches and to treat allergic rhinitis (seasonal allergies). It
has also been studied from the prevention of gastric ulcers and in for
treating cough, asthma, irritable bladder and urinary tract spasms.
Butterbur for Migraine Headaches
Migraine headaches vary in intensity and duration, but many migraine
sufferers describe a debilitating pain made worse with light, sound and
movement. Some experience nausea and vomiting. Migraines in most people
occur without warning; however, in cases of "classic" migraine headache, a
visual disturbance called an aura happens before the headache starts. Other
types of migraines include "common" migraine, which is not preceded by any
warning signs or aura; and "complicated" migraine, which is accompanied by
speech, movement, or other nervous system problems.
One randomized, double-blind, three-arm, parallel-group,
placebo-controlled trial investigated the efficacy of butterbur root extract
(Petadolex®, Weber and Weber GmbH International & Co., Germany) 50 mg, 75 mg
or placebo twice a day for the prevention of migraine headaches.3 Butterbur
extract was standardized to contain at least 15% petasin and isopetasin and
with no detectable pyrrolizidine alkaloids (< 0.008 ppm). Pyrrolizidine
alkaloids can be toxic to the liver, and so removing them increases the
safety profile of butterbur and other plants. The trial lasted 20 weeks,
with an initial 4-week baseline phase followed by a 16-week treatment phase.
Researchers enrolled 229 volunteers (ages 18-65 years, mean age
approximately 48 years) with a history of two to six migraine headaches per
month in the three months prior to treatment, and at least two headaches
during the 4-week baseline phase. Excluded from the trial were people with
migraine headaches lasting greater than six days per month in the three
months prior to the study, women who were at risk of getting pregnant, and
women who were breastfeeding. Treatment with 150 mg/day was the most
effective dose and resulted in a greater than 50% reduction in migraines per
month over baseline after one, two, three and four months in a significant
percentage of patients compared to placebo (54% vs. 33% after one month,
respectively; 60% vs .43% after two months, respectively; 71% vs. 52% after
three months, respectively; 68% vs. 49% after four months, respectively; p <
0.05 at all time periods).
This trial demonstrates the safety and efficacy of 150 mg/day butterbur
in preventing migraine headaches. The authors note the efficacy attained
with 150 mg/day butterbur is comparable to prescription medications (e.g.,
toprimate and gabapentin), while the safety of butterbur appears superior to
these drugs. It is important that only butterbur extracts with the
pyrrolizidine alkaloids (PAs) removed be taken, since the PAs are toxic to
the liver.
Butterbur for Allergic Rhinitis
Allergic rhinitis (AR) is an inflammation of the nasal mucous membranes
caused by environmental allergens such as pollen and dust. It is oftentimes
referred to as hay fever, which is a misnomer, since the allergen is not
necessarily hay, and there is no fever. Symptoms include sneezing, nasal
congestion, nasal itching, and watery nasal discharge. AR affects an
estimated 20% of the population. Commonly, antihistamines are used to treat
AR symptoms; however, antihistamines can cause drowsiness.
Several clinical trials have tested the efficacy of different
preparations of butter extracts on people with AR. One prospective,
randomized, double-blind, parallel group clinical trial compared butterbur (Petasites
hybridus) carbon dioxide extract Ze 339 (Zeller AG, Switzerland) to
fexofenadine (Telfast 180®; Aventis Pharma Limited, New Zealand), a
non-sedating antihistamine, and placebo for the treatment of AR.4 A total of
330 volunteers, 18–80 years old (mean age approximately 38 years) were
randomized to receive 1 tablet butterbur extract Ze 339 (standardized to 8
mg petasine) three times a day, 1 tablet fexofendadine, or placebo for 2
weeks. Butterbur was equally effective as fexofenadine for treating symptoms
of intermittent AR, and both were superior to placebo for decreasing runny
nose, sneezing, itchy nose, itchy/red eyes, and nasal congestion. Although
fexofenadine is considered a non-sedating antihistamine, a large percentage
of volunteers in the fexofenadine group experienced sedation. Butterbur
extract Ze 339 is an effective alternative to fexofenadine in the treatment
of intermittent allergic rhinitis.
A second study comparing butterbur extract Ze 339 to certrizine, an
antihistamine, also showed that this butterbur extract, which was
standardized to contain 8 mg petasine per tablet, was as effective at
decreasing the symptoms of AR as certrizine.1 In contrast to the first
clinical trial, participants in this study took one tablet of Ze 339 four
times daily for two weeks.
Another study, however, did not show benefit of butterbur for AR. This
randomized, placebo-controlled, crossover trial enrolled 35 volunteers with
allergies to extracts of grass, tree or weed pollen were randomized to
receive 50 mg of butterbur (Petaforce, Bioforce Ltd, Irvine, Scotland) twice
daily or matching placebo for two weeks during grass pollen season in June,
July and August 2003 in Scotland.5 Among other outcomes measured,
participants were asked to rate their symptoms, including the nasal symptoms
of “runny nose,” “blocked nose,” “itchy nose” and “sneezing,” and the eye
symptoms included “itchy eyes,” “watery eyes” and “red eyes.” There were no
significant improvements in participants in either study phase.
It is difficult to compare the trials, since they used two different
butterbur extracts. The first two studies used the Ze 339 extract
standardized to petasine content from the aerial part of the butterbur
plant. The authors of the study in which Petaforce was administered did not
define that content of the extract; therefore, it is not possible to compare
the outcomes of these clinical trials. An important point is that plants
standardized to different compounds can have different results. It’s
important when deciding on which formula to purchase that consumers are
aware of the research supporting one formula over another. Petasine,
specifically is known to inhibit the formation of leukotrienes, which are
cell signaling molecules involved in inflammation and AR.
Dosage
For prevention of migraine headaches: Petadolex
150 mg/day
For reducing symptoms of allergic rhinitis: 8
mg petasine from Ze 339 three to four times daily.
Herb-Drug Interactions
No herb-drug interactions have been documented.
Caution
Allergies to any plants in the Asteraceae family
(e.g., echinacea, sunflower, artichoke, milk thistle) increase your risk for
allergic reactions to Butterbur, since it is in the same family as these
other plants. |